The Kanchanaburi train line runs from Thonburi train station in Bangkok to Nam Tok via Kanchanaburi, with a branch line to Suphan Buri. There are two trains a days running from Bangkok Thonburi train station to Nam Tok: the 07.50 departure which is scheduled to arrive in Kanchanaburi at 10.35 and at Nam Tok at 12.35; and the 13.55 departure which is scheduled to arrive at Kanchanaburi at 16.26 and at Nam Tok at 18.30.
In the other direction there are also two two trains a day: the 05.20 departure from Nam Tok arriving at Kanchanaburi at 07.19 and terminating at Thonburi at 10.25; and the 12.55 departure from Nam Tok arriving at Kanchanaburi at 14.48 and terminating at Thonburi at 17.40.
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There are plenty of things to see and do in Kanchanaburi, for further information read the Thailand Life Guides to: